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Gliomas are a group of tumors that originate in the glial cells of the central nervous system. These cells provide support and protection for nerve cells in the brain and spinal cord. Gliomas can vary in severity, and their treatment and prognosis depend on factors such as the type, location, and grade of the tumor. In this article, we will delve into the different aspects of gliomas, including types, signs, symptoms, causes, prevention, treatment, diagnosis, and potential home remedies.
Types of Gliomas
A few of the types of Gliomas are:
- Astrocytomas: These tumors arise from astrocytes, star-shaped cells that support nerve cells. They can occur anywhere in the brain and are further classified into low-grade (slow-growing) and high-grade (fast-growing) tumors.
- Oligodendrogliomas: Originating in oligodendrocytes, cells that produce the fatty substance myelin, these tumors are generally slow-growing and often affect the frontal lobes.
- Ependymomas: These tumors develop in the ependymal cells lining the ventricles of the brain and the central canal of the spinal cord. Ependymomas are most common in children and young adults.
- Brain stem gliomas: These also called diffuse infiltrating brainstem gliomas, or DIPGs, are rare tumors found in the brain stem. They usually cannot be surgically removed because of their remote location, where they intertwine with normal brain tissue and affect the delicate and complex functions this area controls. These tumors occur most often in school-age children where they are responsible for the greatest number of childhood deaths from primary brain tumors.
- Mixed gliomas (also called oligo-astrocytomas): are made up of more than one type of glial cell. Their diagnosis as a distinct tumor type is controversial and may be resolved with genetic screening of tumor tissue. These tumors are often found in the cerebrum and are most common in adult men.
- Optic pathway gliomas: These are a type of low-grade tumor found in the optic nerve or chiasm, where they often infiltrate the optic nerves, which send messages from the eyes to the brain.
Signs and Symptoms
The symptoms of gliomas can vary depending on their location and size. Common signs include:
- Headaches
- Seizures
- Nausea and vomiting
- Changes in personality or mood
- Memory loss
- Difficulty concentrating
- Weakness or numbness in the limbs
- Changes in vision or hearing
Causes of Glioma
The exact cause of gliomas is not well understood. However, certain risk factors may increase the likelihood of developing these tumors, such as:
- Age (more common in older adults)
- Genetic factors
- Exposure to ionizing radiation
- Certain genetic disorders, such as neurofibromatosis and Li-Fraumeni syndrome
Prevention
As the exact causes of gliomas are unclear, preventing their development can be challenging. However, some general lifestyle practices may contribute to overall brain health and reduce the risk of tumors. These include:
- Eating a balanced diet rich in fruits, vegetables, and whole grains
- Regular physical exercise
- Adequate sleep
- Limiting exposure to environmental toxins
- Avoiding unnecessary radiation exposure
Treatment of Glioma
Treatment options for gliomas depend on factors like the tumor type, location, and grade. Common approaches include:
- Surgery: The removal of as much tumor tissue as possible.
- Radiation therapy: Using high-energy rays to target and destroy cancer cells.
- Chemotherapy: Administering drugs to kill cancer cells or slow their growth.
- Targeted therapy: Using drugs that specifically target cancer cells with minimal impact on normal cells.
Diagnosis
Diagnosing gliomas typically involves a combination of imaging tests (MRI, CT scans), neurological examinations, and biopsy. The biopsy allows for the examination of tumor tissue to determine its type and grade.
Home Remedies for Glioma
While home remedies are not a substitute for medical treatment, they may complement traditional therapies and help manage symptoms. These include:
- Diet: A nutrient-rich diet can support overall health during treatment.
- Stress management: Techniques such as meditation and yoga may help alleviate stress and improve well-being.
- Hydration: Staying well-hydrated is crucial, especially during treatments like chemotherapy.
- Supportive care: Seeking emotional support from friends, family, or support groups can be beneficial for both patients and their caregivers.
In Conclusion, Gliomas present a complex challenge in the realm of oncology, requiring a comprehensive approach to diagnosis, treatment, and ongoing care. While advancements in medical science continue to improve outcomes for glioma patients, early detection, prompt intervention, and a holistic approach to health remain crucial elements in managing these tumors effectively.
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FAQ’s
How does Gamma Knife work?
Gamma Knife uses 192–201 precisely focused beams of gamma rays that converge at a single target point in the brain. This high dose of radiation damages the DNA of abnormal cells, stopping their growth or causing them to shrink, while minimizing exposure to nearby healthy tissue.
Is Gamma Knife a surgery?
No, Gamma Knife is not a traditional surgery. It is a non-invasive outpatient procedure performed without any incision, stitches, or general anesthesia in most cases.
What conditions can be treated with Gamma Knife?
Gamma Knife is commonly used for:
Brain tumors (benign and malignant)
Metastatic brain lesions
Arteriovenous malformations (AVMs)
Trigeminal neuralgia
Acoustic neuromas (vestibular schwannomas)
Pituitary tumors
Certain functional disorders (like tremors)
Is Gamma Knife painful?
The procedure is generally painless. Patients may feel mild pressure while the head frame (if used) is applied or may experience slight discomfort from anesthesia injections, but the treatment itself is not painful.
How long does the procedure take?
Depending on the condition and treatment plan, Gamma Knife may take 30 minutes to 3 hours. Most patients go home the same day.
What are the possible side effects?
Common side effects are usually mild and temporary, including:
Headache
Nausea
Fatigue
Mild scalp swelling or tenderness at the frame site
Rarely, some patients may experience delayed radiation effects such as brain swelling or radiation necrosis.
When can the patient return to normal activities after Gamma Knife?
Most patients can return to their normal routine within 24–48 hours after the procedure.
You may feel mild fatigue for a few days.
Follow-up imaging is usually required after 1 year.
How effective is Gamma Knife?
Gamma Knife has a high success rate and has been used worldwide for decades. Its effectiveness depends on the condition treated, size and location of the lesion, and overall patient health. In many cases, it offers results comparable to open surgery with fewer risks.
Can Gamma Knife be repeated if needed?
Yes, in some cases Gamma Knife treatment can be repeated if the disease recurs or if new lesions develop.
Is Gamma Knife safe?
Yes. Gamma Knife is considered one of the safest and most precise forms of radiosurgery, with millions of patients treated globally and extensive clinical data supporting its use.
Who is eligible for Gamma Knife treatment?
Eligibility depends on factors such as:
Size and location of the lesion
Overall health and age
Whether open surgery is too risky
A neurosurgeon and radiation oncologist will decide if Gamma Knife is the best option for you.
What happens before the procedure?
A detailed MRI or CT scan is performed to map the brain.
A lightweight head frame or mask is used for accuracy.
Your doctors plan the radiation dose and target areas using specialized software.
Will I need anesthesia?
Local anesthesia is given if a head frame is used.
General anesthesia is usually not required, except for children or patients unable to remain still.
What is the cost of Gamma Knife in India?
Costs vary depending on hospital, city, and condition treated. On average, Gamma Knife in India ranges from ₹1.5 lakh to ₹4.5 lakh. It is usually more affordable compared to treatment in Western countries. At AIIMS Delhi, it is much more affordable around ₹75,000 which makes it affordable for the patients in need.
Where can I get Gamma Knife treatment in Delhi?
AIIMS Delhi is one of the leading centres for Gamma Knife in India.
- AIIMS uses the latest Gamma Knife Perfexion system.
- It has successfully treated thousands of patients for brain tumors, blood vessel problems, and even eye cancers.
- The treatment is done by expert neurosurgeons such as Dr. Deepak Agrawal and team.
- Clinic timings for Gamma Knife OPD at AIIMS Delhi: Monday & Friday, 8:00 AM – 9:00 AM.
- Cost is around ₹75,000 and is subsidized compared to private hospitals.